ChicagoWhite Sox0-0
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Chicago White Sox @ Chicago Cubs Lines and Odds

CHWWhite Sox0-0
Powerline Rating

Head-to-Head Series History

White Sox

Cubs are 5-5 (50%) in moneyline bets in their last 10 games against CHW for -0.45 total units lost

White Sox

White Sox are 6-4 (60%) in runline bets in their last 10 games against CHC for 1.45 total units won

White Sox

Cubs are 6-4 (60%) in over bets in their last 10 games against CHW for 1.45 total units won

Cubs vs. White Sox Series Betting Preview

For Cubs vs. White Sox betting odds and more, you’ve come to the right place.

This will be a unique version of the Windy City Classic, as the White Sox will have a chance to clinch the AL Central division title and the Cubs can wrap up the NL Central as well. 

The White Sox come into the series after a hard-fought group of games against the Cleveland Indians. The White Sox offense has been dominating this season, and the Cubs pitching staff will be in for a stiff challenge. The Cubs hosted the Pittsburgh Pirates in a four-game set leading up to this series. They’re a club that relies on pitching, as its offense has been inconsistent.

Looking at the World Series betting odds, the White Sox opened the season at +4000 to win it. Thanks to an offensive surge and solid pitching this season, you can now find them at around +1000. The Cubs are at +1600 to win it all. Both teams are fighting for playoff seeding, so keep that in mind when looking at the White Sox vs. Cubs odds.

If you’d like to shop around and compare White Sox vs. Cubs lines across various sportsbooks, as well as other games from around the MLB, take a look at our odds comparison tool. With the odds comparison tool, you get a bird’s eye view of where the odds sit at several sportsbooks, which allows you to shop for the best possible price.

“South Siders” Rolling

The White Sox rotation got on track after a slow start. The Cubs likely will not have to deal with Lucas Giolito or left-hander Dallas Keuchel in this series if the White Sox have already locked up one of the top two seeds in the American League. Keuchel will most likely not make an appearance unless it’s a short outing, so keep that in mind when shopping White Sox vs. Cubs odds.

In the White Sox bullpen, closer Alex Colome, Codi Heuer, and Evan Marshall have made this an exceptional unit, although recent struggles have seen them rank in the top five in bullpen SIERA to a top-seven unit.

Offensively, the White Sox feature young, ascending position players in Eloy Jimenez, Yoan Moncada, and rookie Luis Robert. Shortstop Tim Anderson is in the conversation for AL MVP. Jose Abreu and the rest of this offense are battling the Yankees for the most runs scored per game among American League teams.

Darvish and Hendricks Carrying Cubs Rotation

The Cubs enter this series ranking inside the top 10 in SIERA among starting pitchers and relievers while their offense has struggled.

Yu Darvish and Kyle Hendricks have carried the Cubs starting rotation, while the return of Jose Quintana has added talent and depth to the unit. Jeremy Jeffress, Roman Wick, and Jason Adam lead a bullpen that is surging at the right time. Former all-star closer Craig Kimbrel has found his form in the month of September, making the Cubs bullpen a formidable force heading into the postseason.

On offense, the Cubs bats have gone cold in September, ranking in the bottom five in baseball in runs scored. Anthony Rizzo, Kris Bryant, and Kyle Schwarber will have to arise from their September swoon in order to keep pace with the South Sider’s high-powered offense.

Expect the White Sox and Cubs to be evenly matched this series, so keep that in mind when you review the White Sox vs. Cubs odds.



  • Austin Romine (C) Romine is nursing a knee injury, and it is undetermined if he will suit up April 1 versus the Pirates. 03/12 · Questionable · Knee
  • Rowan Wick (RP) Wick is battling an intercostal injury, and it is uncertain if he will be available against the Pirates in the season opener. 03/04 · Questionable · Ribs
  • D.J. Snelten (RP) Snelton is sidelined with an elbow injury, and he is projected to miss at least six weeks. 02/24 · Out · Elbow

CHWWhite Sox

  • Yasmani Grandal (C) Grandal is battling a right knee sprain, but it is anticipated that he will suit up against the Angels in the season opener. 03/11 · Probable · Knee
  • Adam Engel (CF) Engel has a strained right hamstring, and it is unclear if he will be good to go for the season opener versus the Angels. 03/20 · Questionable · Hamstring
  • Jimmy Cordero (RP) Cordero will miss the entire 2021 season after undergoing Tommy John surgery on his right elbow. 03/19 · Out · Elbow
  • Nick Madrigal (2B) Madrigal is expected to be out of the lineup until at least the middle of April due to left shoulder surgery. 11/07 · Out · Shoulder